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The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubricati

The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubrication By Heidi Reesink Abstract ... and galectins-1 and -3 to determine if lubricin and galectins could synergistically enhance articular cartilage boundary lubrication and; 3) evaluate equine ...

Regulation of lubricin for functional cartilage tissue regeneration: a review | Biomaterials Research | Full Te

The fundamental role of lubricin is lubrication of boundary surface of cartilage []. Hence, transmutation of lubricin metabolism would conspicuously influence joint performance. In fact, patients who suffer from osteoarthritis (OA), degenerative joint disease, or ...

NAVER Academic > Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosi

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Author Kimberly A Waller, Ling X Zhang, Khaled A Elsaid, Braden C Fleming, Matthew L Warman, Gregory D Jay Publisher ...

The role of lubricin in the mechanical behavior of synovial flui

The role of lubricin in the mechanical behavior of synovial fluid. Jay G.D., Torres J.R., Warman M.L., ... where it contributes to boundary lubrication under load. Individuals with genetic deficiency of lubricin develop precocious joint failure. The role of lubricin in We ...

Stribeck Analysis Of Synovial Lubricants: Lubricating Mechanisms And Interaction Of Hyaluronic Acid And Lubric

lubricants: lubricin and hyaluronic acid. Lubricin is an effective boundary lubricant, hyaluronic acid works as a viscosupplement, and interaction between the two lubricants may facilitate changes in lubrication mode. Acknowledgments: The Authors thank the NSF ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | PN

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | Request P

Request PDF on ResearchGate | Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and ...

Lubrication by biomacromolecules: mechanisms and biomimetic strategies - IOPscien

Waller K A, Zhang L X, Elsaid K A, Fleming B C, Warman M L and Jay G D 2013 Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Proc. Natl Acad. Sci. USA 110 5852–7 ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

National Academy of Sciences Contact Feedback Submit Subscribe Keyword, Author, or DOI GO Advanced Search ... number of apoptotic chondrocytes. These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival ...

Stimulation of Superficial Zone Protein/Lubricin/PRG4 by Transforming Growth Factor-β in Superficial Zone Articular Chondrocytes and Modulation .

Superficial zone protein (SZP), also known as lubricin and proteoglycan 4 (PRG4), plays an important role in the boundary lubrication of articular cartilage and is regulated by transforming growth factor (TGF)-β. Here, we evaluate the role of cell surface ...

The role of lubricin in the mechanical behavior of synovial fluid | G D Jay | Request P

Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA–protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

Lubricin: New Promise for Joint-Preserving Therapy | Rheumatology Netwo

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci (2013) 110:5852-5857 23. Waller KA, Zhang LX, Fleming BC, Jay GD. Preventing friction-induced chondrocyte apoptosis: comparison of human synovial fluid ...

Lubricin: a novel potential biotherapeutic approaches for the treatment of osteoarthritis | SpringerLi

Osteoarthritis (OA) is a multi-factor disorder of sinovial joints, which characterized by escalated degeneration and loss of articular cartilage. Treatment of OA is a critical unmet ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

The role of lubricin in the mechanical behavior of synovial flu

Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA–protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

Proteoglycan 4 - Wikiped

Function Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP).

The role of lubricin in normal and pathological joint tissue: A contemporary review.OA Anato

The role of lubricin in normal and pathological joint tissue: a contemporary review G Musumeci 1* Authors affiliations (1) ... It has been shown that lubricin is critical to normal joint function, providing boundary lubrication of congruent articular surfaces under ...

Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication | SpringerLi

Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication Authors Authors and affiliations ...

Both Hyaluronan and Collagen Type II Keep Proteoglycan 4 (Lubricin) at the Cartilage Surface in a Condition That Provides Low Friction during .

Wear resistant and ultralow friction in synovial joints is the outcome of a sophisticated synergy between the major macromolecules of the synovial fluid, e.g., hyaluronan ... Abstract: Glycoproteins, such as lubricin, and hyaluronic acid (HA) play a prominent role in ...

Transcription, Translation, and Function of Lubricin, a Boundary Lubricant, at the Ocular Surface | Cornea | JAMA Ophthalmology | JAMA Netwo

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, ... responsible for boundary mode lubrication at the ocular surface supports the hypothesis of Ehlers, 28 who theorized that boundary lubrication must 29 ...